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J Am Chem Soc. 2009 Sep 9;131(35):12522-3. doi: 10.1021/ja903408r.

G-quadruplex DNA bound by a synthetic ligand is highly dynamic.

Author information

1
Department of Physics, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Abstract

Using single molecule fluorescence resonance energy transfer, we investigated the interaction between a quadruplex-binding ligand and the human telomeric G-quadruplex. The binding of quinolinecarboxamide macrocycle to telomeric DNA was essentially irreversible and selectively induced and favored one quadruplex conformation. The ligand-quadruplex complex displayed intramolecular dynamics including quadruplex folding and unfolding in the absence of ligand association and dissociation. We report that the G-quadruplex can be stabilized without preventing the intrinsic intramolecular dynamics of telomeric DNA.

PMID:
19685880
PMCID:
PMC2737377
DOI:
10.1021/ja903408r
[Indexed for MEDLINE]
Free PMC Article

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