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Nat Neurosci. 2009 Sep;12(9):1087-9. doi: 10.1038/nn.2382. Epub 2009 Aug 16.

Midline crossing and Slit responsiveness of commissural axons require USP33.

Author information

1
Department of Neurology, Lurie Comprehensive Cancer Center, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Abstract

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

PMID:
19684588
PMCID:
PMC3893063
DOI:
10.1038/nn.2382
[Indexed for MEDLINE]
Free PMC Article

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