Format

Send to

Choose Destination
Nat Med. 2009 Sep;15(9):1013-5. doi: 10.1038/nm.1995. Epub 2009 Aug 16.

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.

Author information

1
Gastroenterology, University Tor Vergata of Rome, Rome, Italy.

Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

PMID:
19684581
DOI:
10.1038/nm.1995
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center