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Genes Dev. 2009 Aug 15;23(16):1843-8. doi: 10.1101/gad.1838109.

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.

Author information

1
Institut Biologie du Développement et Cancer-IBDC, Université de Nice-Sophia Antipolis, CNRS UMR 6543, Centre de Biochimie, Nice Cedex 02, France.

Abstract

The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the transduction of the Hh signal, notably regarding the role of primary cilia in mammalian cells. In this issue of Genes & Development, Chen and colleagues (pp. 1910-1928) demonstrate that mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner.

PMID:
19684109
PMCID:
PMC2725945
DOI:
10.1101/gad.1838109
[Indexed for MEDLINE]
Free PMC Article

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