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J Antimicrob Chemother. 2009 Oct;64(4):680-3. doi: 10.1093/jac/dkp275. Epub 2009 Aug 14.

Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in China.

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1
The State Food and Drug Administration, Beijing, People's Republic of China.

Abstract

OBJECTIVES:

The objectives of this study were to determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in livestock and related workers in four Chinese provinces and the characteristics of these isolates.

METHODS:

Nasal swabs were collected from animals and farm workers in four Chinese provinces. MRSA isolates were recovered and characterized by PFGE, Panton-Valentine leucocidin PCR, staphylococcal chromosomal cassette (SCC) mec typing, spa typing, multilocus sequence typing, antimicrobial susceptibility testing and testing for inducible clindamycin resistance.

RESULTS:

A total of 60 MRSA isolates were recovered from swine and swine workers. Two predominant multidrug resistance profiles were identified: ciprofloxacin/clindamycin/erythromycin/cefoxitin/gentamicin/tetracycline/chloramphenicol and ciprofloxacin/clindamycin/erythromycin/cefoxitin/gentamicin/tetracycline. All isolates were determined to be spa type t899, contained the group III SCCmec element and were Panton-Valentine leucocidin negative. Multilocus sequence type ST9 (n = 46) was identified as the dominant sequence type. One dominant PFGE cluster and a dominant strain type were identified.

CONCLUSIONS:

MRSA from Chinese pigs and farm workers (ST9) differed from the European pig-associated clone (ST398) with regard to clonal type, SCCmec content and resistance profile.

PMID:
19684078
DOI:
10.1093/jac/dkp275
[Indexed for MEDLINE]

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