Send to

Choose Destination
Vaccine. 2009 Oct 9;27(43):6030-3. doi: 10.1016/j.vaccine.2009.07.099. Epub 2009 Aug 12.

Hepatitis B vaccination failure in celiac disease: is there a need to reassess current immunization strategies?

Author information

Broncho-Pneumology & Cystic Fibrosis Unit, Department of Pediatrics, University of Catania, Catania, Italy.


Human leukocyte antigen (HLA) phenotype DQ2 is considered the most important genetic marker for un-responsiveness to hepatitis B vaccine. Since celiac disease (CD) is also strongly associated with the same haplo-type it may be hypothesized that celiac patients are less able to respond to the vaccine. We report a retrospective study on celiac patients vaccinated with three doses of 10 microg at 3, 5 and 11 months of age by an intramuscular injection of a recombinant hepatitis B vaccine (Engerix B). We found 30 of 60 celiac patients (50%) unresponsive to vaccination and a significant higher number of responders among patients younger than 18 months at the time of celiac disease diagnosis. Our study confirms that celiac patients have a lower percentage of response to hepatitis B vaccination than healthy subjects. These findings provide useful information to evaluate if current vaccine strategies should be reassessed and if revaccination should be recommended.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center