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J Am Geriatr Soc. 2009 Sep;57(9):1580-6. doi: 10.1111/j.1532-5415.2009.02402.x. Epub 2009 Aug 4.

Effect of influenza vaccination of nursing home staff on mortality of residents: a cluster-randomized trial.

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Department of Epidemiology, Information Systems, and Modeling, University Pierre and Marie Curie Paris 6, UMR-S 707, Paris, France.



To evaluate the effect of staff influenza vaccination on all-cause mortality in nursing home residents.


Pair-matched cluster-randomized trial.


Forty nursing homes matched for size, staff vaccination coverage during the previous season, and resident disability index.


All persons aged 60 and older residing in the nursing homes.


Influenza vaccine was administered to volunteer staff after a face-to-face interview. No intervention took place in control nursing homes.


The primary endpoint was total mortality rate in residents from 2 weeks before to 2 weeks after the influenza epidemic in the community. Secondary endpoints were rates of hospitalization and influenza-like illness (ILI) in residents and sick leave from work in staff.


Staff influenza vaccination rates were 69.9% in the vaccination arm versus 31.8% in the control arm. Primary unadjusted analysis did not show significantly lower mortality in residents in the vaccination arm (odds ratio=0.86, P=.08), although multivariate-adjusted analysis showed 20% lower mortality (P=.02), and a strong correlation was observed between staff vaccination coverage and all-cause mortality in residents (correlation coefficient=-0.42, P=.007). In the vaccination arm, significantly lower resident hospitalization rates were not observed, but ILI in residents was 31% lower (P=.007), and sick leave from work in staff was 42% lower (P=.03).


These results support influenza vaccination of staff caring for institutionalized elderly people.

[Indexed for MEDLINE]

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