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FEBS J. 2009 Oct;276(19):5447-55. doi: 10.1111/j.1742-4658.2009.07229.x. Epub 2009 Aug 13.

The miRNA-192/194 cluster regulates the Period gene family and the circadian clock.

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1
Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Abstract

Several biological functions in mammals are regulated in a circadian fashion. The molecular mechanisms orchestrating these circadian rhythms have been unravelled. The biological clock, with its core transcriptional unit Bmal1/CLOCK, is composed of several self-sustaining feedback loops. In this study, we describe another mechanism impinging on the core components of the circadian clock. Using a forward genetic screen, we identified the miR-192/194 cluster as a potent inhibitor of the entire Period gene family. In accordance, the exogenous expression of miR-192/194 leads to an altered circadian rhythm. Thus, our results have uncovered a new mechanism for the control of the circadian clock at the post-transcriptional level.

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