Abstract
The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney disease (CKD) and six hyperthyroid (HT) cats to assess potential differences in glomerular filtration rate (GFR) measurement over a wide range of GFR values. The PECCT, PexICT and PenICT were performed in a combined protocol. There was a significant difference between PexICT and PenICT and PECCT in healthy cats. Differences between clearance techniques are suggested to be correlated to range in GFRs and should be taken into account when GFR is measured.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Cat Diseases / metabolism*
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Cat Diseases / radiotherapy
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Cats / blood*
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Creatinine / pharmacokinetics*
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Female
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Glomerular Filtration Rate / veterinary*
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Hyperthyroidism / metabolism
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Hyperthyroidism / radiotherapy
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Hyperthyroidism / veterinary*
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Iodine / therapeutic use
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Iodine Radioisotopes / therapeutic use
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Iohexol / pharmacokinetics*
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Kidney Diseases / diagnosis
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Kidney Diseases / veterinary*
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Male
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Radiopharmaceuticals / pharmacokinetics
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Reference Values
Substances
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Iodine Radioisotopes
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Radiopharmaceuticals
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Iohexol
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Iodine
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Creatinine