Format

Send to

Choose Destination
Diagn Microbiol Infect Dis. 2009 Sep;65(1):27-34. doi: 10.1016/j.diagmicrobio.2009.05.007.

Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance Program.

Collaborators (266)

Finquelievich J, Tiraboschi N, Finquelievich J, Adelaide DE, Chen S, Frameree D, van den Abeele AM, Senterre JM, Colombo AL, Kiffer CR, Rennie R, Sanche S, Bijie H, Xu Y, Fu W, Zhong NS, Yun-Song Y, Rivas P, Bedout C, Mendez M, Mallatova N, Dobiasova S, Ayabaca J, Zurita J, Mallie M, Candolf E, Dupont B, Sequela JP, Fegeler W, Haas, Shah PM, Braveny I, Bernhardt H, Haase G, Rodloff A, Baer W, Gobel U, Czaika V, Petrikos G, Hui M, Majoros L, Ildiko S, Konkoly-Thege M, Barcs I, Nagy E, Gam T, Nikolova R, Banerjee U, Wahyuningsih R, Susilo J, Tel-Hashomer NK, Tullio V, Schito GC, Fortina G, Testore GP, D'Antonio D, Scalise G, Girmenia C, Manno G, Igari J, Peng NG, Alpuche C, Noriega ER, Morfin R, Zaidi M, Meis JF, Meis J, Lingaas E, Zurita S, Dzierzanowska D, Polowniak-Pracka H, Pawliszyn W, Martins Mda L, Albuquerque L, Rosado L, Velho R, Lopes V, da Fonsesca JH, Stratchounski L, Evgenievna KL, Kretchikova OI, Klyasova GA, Rozanova, Multykh IG, Klimko NN, Agapova ED, Dmitrieva NV, Al-Rasheed AM, Shibl AM, Ling TA, Oon L, Fandakova I, Trupl J, Langsadl L, Lisalova M, Vaculikova A, Helena H, Roditi D, Pillay D, Hoosen A, Wadula J, van Rensburg MN, Duse A, Lee K, Lee MK, Kim MN, del Palacio A, Baquero F, Bille J, Muhlethaler K, Ko WC, Chang SC, Wang JH, Yu KW, Vorachit M, Tharavichitkul P, Gur D, Korten V, Paul J, Jones B, Gould FK, Brown D, Kibbler C, Petrou M, Weightman N, Gould IM, Rennison C, Barton R, Barnes R, Vazquez J, Vazquez J, Chan E, Larone D, Chaturvedi V, Baron EJ, Hindler J, Ghannoum M, Rinaldi M, Hazen K, Foraker E, Reyes H, Santiago A, Tiraboschi IN, Finquelievich J, Ellis D, Chen S, Halliday C, Pasqualotto AC, Colombo AL, Martino MD, Hoban D, Rennie R, Sanche S, Guzman AM, Wang F, Bijie H, Zhong N, Xu Y, Y U Y, de Bedout C, Restrepo A, Rivas Jdel P, Quevedo R, Mendez M, Mallatova N, Dobiasova S, Zurita J, Ayabaca J, Koukila-Kähkölä P, Cassaing S, Nagy E, Nikolova R, Keller N, D'Antonio D, Manno sG, Fortina G, Andreoni S, Raponi G, Ghezzi MC, Testore GP, Schito G, Soro O, Scalise G, Martino P, Tullio V, Lee K, Yong D, Lee MK, Kim MN, Peng NK, Noriega ER, Morfín R, Santos JI, Alpuche-Aranda CM, Zaidi M, Meis JF, Dzierzanowska D, Garczewska B, Szygula U, Amorim J, Lopes V, Da Fonseca JC, Albuquerque L, Alves AF, Martins Mda L, Jorge R, Rosado L, Verissímo C, Velho R, Kliasova G, Dmitrieva NV, Vaculikova A, Trupl J, Hupkova H, Fandakova I, Lisalova M, Duse A, Hoosen A, Crewe-Brown HH, Roditi D, van Rensburg MN, Wende L, del Palacio A, Canton R, Yu KW, Wang JH, Vorachit M, Gur D, Korten V, Mulazimoglu L, Gould I, Weightman N, Galloway A, Herring A, Segal B, Suh B, Kauffman C, Bruckner D, Horn D, Larone D, Sussland D, Hardy DJ, Baron EJ, Doern G, Hall GS, Nguyen H, Rankin I, Jorgensen J, Thompson J, DiPersio JR, Vazquez J, Dolan J, Carroll K, Van Horn K, Hazen K, Steele-Moore L, Ghannoum M, Appelbaum P, Shoham S, Davis T, Chaturvedi V, Nolte R, Stockton M, Santiago A, Guzman M, Reyes H.

Author information

1
Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. michael-pfaller@uiowa.edu

Abstract

The accuracy of antifungal susceptibility testing is important for reliable resistance surveillance and for the clinical management of patients with serious infections due to Candida spp. Our primary objective was to compare the results of fluconazole and voriconazole disk diffusion testing of 3227 Candida spp. performed by 47 centers participating in the ARTEMIS program with disk diffusion and MIC results obtained by the central reference laboratory. The overall categoric agreement between participant disk diffusion test results and reference MIC results was 87% for fluconazole and 95.2% for voriconazole. Likewise good agreement was observed between participant disk diffusion test results and reference laboratory disk diffusion test results, with an agreement of 90.5%, 1% very major error (VME), and 3.4% major error (ME) for fluconazole and 94.2%, 1.1% VME, and 2.5% ME for voriconazole. The disk diffusion test was reliable for detecting those isolates of Candida spp. that were characterized as resistant to fluconazole and voriconazole by MIC testing. External quality assurance data obtained by surveillance programs such as the ARTEMIS Global Antifungal Surveillance Program ensure the generation of useful surveillance data and result in the continued improvement of antifungal susceptibility testing protocols.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center