Format

Send to

Choose Destination
Neuron. 2009 Aug 13;63(3):281-4. doi: 10.1016/j.neuron.2009.07.020.

The pre/post LTP debate.

Author information

1
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454-9110, USA. lisman@brandeis.edu

Abstract

The pre/post debate involves the question of whether long-term potentiation (LTP) is mediated by enhancement of release, enhancement of postsynaptic receptors, or both. Recent papers have presented evidence for purely postsynaptic or purely presynaptic changes, and a paper by Ahmed and Siegelbam (in this issue of Neuron) suggests a mechanism by which release is enhanced. This debate is increasingly constrained by technical advances that allow central synapses to be studied with increasing precision. A possible of way of reconciling conflicting evidence is suggested.

PMID:
19679068
DOI:
10.1016/j.neuron.2009.07.020
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center