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Physiology (Bethesda). 2009 Aug;24:245-9. doi: 10.1152/physiol.00009.2009.

What's new about osmotic regulation of glycerophosphocholine.

Author information

1
Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

Glycerophosphocholine is an abundant renal medullary organic osmolyte that protects renal medullary cells from the high interstitial concentrations of NaCl and urea to which they are normally exposed. We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance.

PMID:
19675355
PMCID:
PMC2943332
DOI:
10.1152/physiol.00009.2009
[Indexed for MEDLINE]
Free PMC Article

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