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Eur J Neurol. 2010 Jan;17(1):136-42. doi: 10.1111/j.1468-1331.2009.02765.x. Epub 2009 Aug 5.

Open muscle biopsy in suspected myopathy: diagnostic yield and clinical utility.

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Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.



The purpose of the study was to investigate the diagnostic yield and clinical utility of open muscle biopsy and to identify pre-biopsy factors that might predict useful clinical results for suspected myopathy.


Two-hundred fifty-eight muscle biopsies, performed for investigation of suspected myopathy, were evaluated.


A specific clinical diagnosis following muscle biopsy was made in 43% of cases. As a result of the biopsy, clinical diagnosis was changed in 47% and treatment was changed in 33% of cases. Results either led to a specific clinical diagnosis or changed the diagnosis/treatment in 74% of patients. Positive family history of myopathy and findings of myopathic irritability on electromyography had a negative predictive value for diagnosis change.


Open muscle biopsy is useful in myopathy evaluation in the modern genetic era.

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