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Eur J Neurol. 2010 Jan;17(1):143-6. doi: 10.1111/j.1468-1331.2009.02767.x. Epub 2009 Aug 5.

The CST3 B haplotype is associated with frontotemporal lobar degeneration.

Author information

1
NeuroBioGen Lab-Memory Clinic, IRCCS "S. Giovanni di Dio-FBF", Brescia, Italy.

Abstract

BACKGROUND AND PURPOSE:

Frontotemporal lobar degeneration (FTLD) is a common cause of early-onset dementia. Given the role of cystatin C in brain neurodegeneration and neuroregeneration, the aim of this study was to determine whether the cystatin C gene (CST3) was genetically associated with FTLD.

METHODS:

Hundred and eighty-six FTLD patients and 457 controls underwent CST3 analysis by PCR and KspI enzyme digestion.

RESULTS:

In FTLD patients negative for the presence of PGRN mutations, we found an over-representation of the CST3 haplotype B [odds ratio (OR = 1.619, P = 0.002)] and of AB/BB genotypes (OR = 1.704, P = 0.008) in FTLD patients.

CONCLUSIONS:

The present study indicated the CST3 B haplotype as a putative risk factor for FTLD in PGRN mutations negative patients. The reduced level of cystatin C, previously associated with the B haplotype, might represent the molecular factor responsible for the increased risk. Long-term depletion of neurotrophic factors, such as cystatin C and progranulin proteins, seem to be a common theme in FTLD: boosting the expression of such proteins might be a promising therapeutic strategy for FTLD.

[Indexed for MEDLINE]

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