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Eur J Immunol. 2009 Aug;39(8):2011-4. doi: 10.1002/eji.200939542.

Animal models of tuberculosis.

Author information

1
Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK. d.young@imperial.ac.uk

Abstract

There is a wide range of animal models of tuberculosis; which is fortunate, given that there is a wide range of complex biological phenomena to model. Nonetheless, the inadequacy of animal models is a chronic grievance amongst researchers, often expressed in the conclusion that the mouse is not a good model of human tuberculosis. There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research.

PMID:
19672894
DOI:
10.1002/eji.200939542
[Indexed for MEDLINE]
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