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Nat Rev Mol Cell Biol. 2009 Sep;10(9):644-50. doi: 10.1038/nrm2746. Epub 2009 Aug 12.

Biology under construction: in vitro reconstitution of cellular function.

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1
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Abstract

We are much better at taking cells apart than putting them together. Reconstitution of biological processes from component molecules has been a powerful but difficult approach to studying functional organization in biology. Recently, the convergence of biochemical and cell biological advances with new experimental and computational tools is providing the opportunity to reconstitute increasingly complex processes. We predict that this bottom-up strategy will uncover basic processes that guide cellular assembly, advancing both basic and applied sciences.

PMID:
19672276
PMCID:
PMC2937256
DOI:
10.1038/nrm2746
[Indexed for MEDLINE]
Free PMC Article
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