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J Biol Phys. 2009 Oct;35(4):317-36. doi: 10.1007/s10867-009-9157-9. Epub 2009 May 14.

Astrocyte-neuron interactions in neurological disorders.

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Neurologic Clinic, University of Pisa, Pisa, Italy.


Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modulation. Astrocytes are, in fact, part of a bidirectional crosstalk with neurons. Moreover, increasing evidence is stressing the emerging role of astrocyte dysfunction in the pathophysiology of neurological disorders, including neurodegenerative disease, stroke, epilepsy, migraine, and neuroinflammatory diseases.

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