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Hepatol Int. 2008 Dec;2(4):498-9. doi: 10.1007/s12072-008-9099-5. Epub 2008 Oct 2.

Reactivation of chronic hepatitis B infection related to imatinib mesylate therapy.

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Section of Gastroenterology and Hepatology, Washington Hospital Center, Georgetown University School of Medicine, 110 Irving Street NW, Washington, DC, 20010, USA.


Imatinib (Gleevec, Novartis), an inhibitor of BCR-ABL, platelet-derived growth factor, and KIT receptor tyrosine kinases, is widely used in the treatment of chronic myelogenous leukemia and gastrointestinal stromal tumors. We describe a case of activation of chronic hepatitis B infection associated with imatinib therapy.

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