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Mol Biosyst. 2009 Sep;5(9):1051-7. doi: 10.1039/b905821b. Epub 2009 Jul 8.

The topology of drug-target interaction networks: implicit dependence on drug properties and target families.

Author information

1
Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Institut Municipal d'Investigació Mèdica, Parc de Recerca Biomèdica, Doctor Aiguader 88, Catalonia, 08003 Barcelona, Spain. jmestres@imim.es

Abstract

The availability of interaction data between small molecule drugs and protein targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of network theory to the analysis of these data reveals an unexpectedly complex picture of drug-target interactions. The results confirm that the topology of drug-target networks depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.

PMID:
19668871
DOI:
10.1039/b905821b
[Indexed for MEDLINE]

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