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Clin Ophthalmol. 2009;3:147-54. Epub 2009 Jun 2.

Treatment of cystoid macular edema with the new-generation NSAID nepafenac 0.1%.

Author information

1
University of Chicago, Department of Ophthalmology and Visual Sciences, Chicago, IL, USA. retina@uchicago.edu

Abstract

PURPOSE:

To describe the use of nepafenac 0.1% for cystoid macular edema (CME).

METHODS:

This was a multicenter retrospective review of 22 CME cases (20 patients) treated with nepafenac 0.1% (six with concomitant prednisolone acetate 1%) from December 2005 to April 2008: three acute pseudophakic CME cases, 13 chronic/recalcitrant pseudophakic CME cases, and six cases of uveitic CME. Pre- and post-treatment retinal thickness and visual acuity were reported.

RESULTS:

Following treatment for six weeks to six months, six eyes with uveitic CME showed a mean retinal thickness improvement of 227 +/- 168.1 mum; mean best-corrected visual acuity (BCVA) improvement was 0.36 +/- 0.20 logMAR. All three cases of acute pseudophakic CME improved after four to 10 weeks of nepafenac, with a mean improvement in retinal thickness of 134 +/- 111.0 mum. BCVA improved in two patients (0.16 and 0.22 logMAR) but not in the third due to underlying retinal pigment epithelium changes. Thirteen eyes with chronic/recalcitrant pseudophakic CME demonstrated a mean improvement in retinal thickness of 178 +/- 128.7 mum after nepafenac and mean BCVA improvement of 0.33 +/- 0.19 logMAR.

CONCLUSION:

The positive outcomes of these 22 eyes strongly suggest that nepafenac 0.1% is a promising drug for the treatment of CME. Additional study under randomized controlled conditions is warranted.

KEYWORDS:

NSAID; cataract surgery; macular edema; nepafenac; uveitis

PMID:
19668559
PMCID:
PMC2709014

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