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Nat Methods. 2009 Sep;6(9):663-6. doi: 10.1038/nmeth.1359. Epub 2009 Aug 9.

A customized and versatile high-density genotyping array for the mouse.

Author information

1
The Jackson Laboratory, Bar Harbor, Maine, USA.

Abstract

We designed a high-density mouse genotyping array containing 623,124 single-nucleotide polymorphisms that captures the known genetic variation present in the laboratory mouse. The array also contains 916,269 invariant genomic probes targeted to functional elements and regions known to harbor segmental duplications. The array opens the door to the characterization of genetic diversity, copy-number variation, allele-specific gene expression and DNA methylation, and will extend the successes of human genome-wide association studies to the mouse.

PMID:
19668205
PMCID:
PMC2735580
DOI:
10.1038/nmeth.1359
[Indexed for MEDLINE]
Free PMC Article

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