Format

Send to

Choose Destination
See comment in PubMed Commons below
Psychiatr Genet. 2009 Apr;19(2):99-101. doi: 10.1097/YPG.0b013e32832080ce.

No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression.

Author information

1
Departments of aPsychiatry bRadiology, University of Bonn, Germany. Jessen@uni-bonn.de

Abstract

Recently, an association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in patients with major depression has been reported. Here, we aimed at replicating this finding in an independent German sample. We included 79 patients with unipolar major depressive episodes and 84 healthy comparison participants. The brain-derived neurotrophic factor Val66Met polymorphism was determined in all participants. The volume of the hippocampus was manually traced on high-resolution magnetic resonance images. The hippocampal volumes of patients were significantly smaller than those of the comparison participants, confirming previous reports. There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants.

PMID:
19668114
DOI:
10.1097/YPG.0b013e32832080ce
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center