Format

Send to

Choose Destination
Transplantation. 2009 Aug 15;88(3 Suppl):S50-3. doi: 10.1097/TP.0b013e3181af7d17.

Gene expression profiling and transplantation tolerance in the clinic.

Author information

1
Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBERehd, Villaroel 170, 08036, Barcelona, Spain.

Abstract

Stable graft function in the absence of maintenance immunosuppressive therapy (IS) is observed in some kidney recipients and in approximately 20% of liver recipients. Identification of these "operationally tolerant" recipients would constitute a major achievement in that it would allow for the widespread application of IS minimization strategies in the clinic. The use of gene expression profiling has provided promising results in the characterization of tolerant transplant recipients. We review here the available information on the use of transcriptional biomarkers to identify transplantation tolerance in the clinic and discuss some of the limitations of such strategy.

PMID:
19667962
DOI:
10.1097/TP.0b013e3181af7d17
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center