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Arch Neurol. 2009 Aug;66(8):979-84. doi: 10.1001/archneurol.2009.142.

Affect of seizures during gestation on pregnancy outcomes in women with epilepsy.

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1
School of Public Health, Taipei Medical University, Taipei, Taiwan.

Abstract

OBJECTIVE:

To assess whether seizures in women with epilepsy during pregnancy contribute to adverse pregnancy outcomes.

DESIGN:

A retrospective cross-sectional study.

SETTING:

Taiwan. Patients This study linked 2 nationwide population-based data sets: Taiwan's birth certificate registry and the Taiwan National Health Insurance Research Data set. A total of 1016 women with epilepsy were selected who had single births from 2001 to 2003 and who had been diagnosed with epilepsy within 2 years prior to their index delivery, together with 8128 matched women without chronic disease as a comparison cohort. Women with epilepsy were further stratified into 2 groups for analysis: women who did and did not have seizures during pregnancy.

MAIN OUTCOME MEASURES:

Low-birth-weight infants, preterm delivery, and infants who are small for gestational age (SGA).

RESULTS:

Compared with women without epilepsy, epileptic seizures during pregnancy were independently associated with a 1.36-fold (95% confidence interval [CI], 1.01-1.88), 1.63-fold (95% CI, 1.21-2.19), and 1.37-fold (95% CI, 1.09-1.70) increased risk of low-birth-weight infants, preterm delivery, and SGA, respectively, after adjusting for family income and parental and infant characteristics. Further, the risk of SGA increased significantly (odds ratio, 1.34; 95% CI, 1.01-1.84) for women with seizures during pregnancy compared with women with epilepsy who did not have seizures during pregnancy.

CONCLUSION:

We suggest preventing seizures during pregnancy as an essential step to reduce risk of adverse pregnancy outcomes.

PMID:
19667219
DOI:
10.1001/archneurol.2009.142
[Indexed for MEDLINE]
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