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Cell. 2009 Aug 7;138(3):428-30. doi: 10.1016/j.cell.2009.07.021.

DNA makes RNA makes innate immunity.

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1
School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland. laoneill@tcd.ie

Abstract

Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.

PMID:
19665965
DOI:
10.1016/j.cell.2009.07.021
[Indexed for MEDLINE]
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