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Gastrointest Endosc. 2009 Dec;70(6):1220-4. doi: 10.1016/j.gie.2009.05.038. Epub 2009 Aug 8.

Preliminary experience with a new cytology brush in EUS-guided FNA.

Author information

1
Department of Gastro-Hepatology, Molinette Hospital, Torino, Italy.

Abstract

BACKGROUND:

Despite the high diagnostic yield of EUS-guided FNA, room for technical improvements remains. Recently, the EchoBrush (Cook Endoscopy, Winston-Salem, NC), a disposable cytologic brush, was introduced to the market. To date, only 1 study, limited to 10 pancreatic cyst cases, using this device has been published.

OBJECTIVE:

To assess the diagnostic yield of the EchoBrush in a cohort of consecutive patients, irrespective of the target lesion.

DESIGN:

Case series.

SETTING:

Tertiary care university hospital (Molinette Hospital, Turin, Italy).

PATIENTS:

Thirty-nine consecutive patients (12 with solid pancreatic masses, 12 with pancreatic cysts, 7 with enlarged lymph nodes, and 8 with submucosal masses) were enrolled.

INTERVENTIONS:

The material collected with the EchoBrush and with a standard FNA needle was double-blind evaluated by 2 cytopathologists.

MAIN OUTCOME MEASUREMENTS:

Adequacy of the sample and sensitivity and specificity of the EchoBrush method.

RESULTS:

Adequate material for cytologic analysis was collected in 17 of 39 patients (43.6%) with a single pass of the EchoBrush. Results were better for pancreatic lesions (for solid and cystic lesions, the adequacy was 58.3% and 50%, respectively); adequacy was low (28.6% and 25%, respectively) for lymph nodes and submucosal masses. The overall sensitivity and specificity were 57.9% and 31.2%, respectively. There were no adverse events with the procedure.

LIMITATION:

Preliminary study.

CONCLUSIONS:

This report suggests that the EchoBrush may provide adequate cellularity to diagnose solid and cystic pancreatic lesions. More extensive studies are needed to compare the EchoBrush and standard needles.

PMID:
19665706
DOI:
10.1016/j.gie.2009.05.038
[Indexed for MEDLINE]

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