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Pediatr Neurol. 2009 Sep;41(3):204-6. doi: 10.1016/j.pediatrneurol.2009.03.019.

Residual and persistent Adie's pupil after pediatric ophthalmoplegic migraine.

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Division of Child Neurology, Department of Pediatrics, University of Rome La Sapienza, Viale Regina Elena 324, Rome 00161, Italy.


We report on a 9-year-old girl diagnosed with ophthalmoplegic migraines who had been previously diagnosed, at age 7 years, with typical migraines with aura. After resolution of the third ophthalmoplegic migraine attack, the only evident residual clinical sign was Adie's pupil. During 24-month follow-up, at age 11 years, a neurologic examination produced completely normal results. However, Adie's pupil persisted. Adie's tonic pupil can be associated with extraocular diseases, which were all excluded in this patient. The mechanisms underlying tonic pupil are not fully understood. This is the first report, to the best of our knowledge, of an ophthalmoplegic migraine followed by persistent Adie's pupil. Possible pathogenic mechanisms are discussed.

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