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J Biol. 2009;8(7):64. doi: 10.1186/jbiol164. Epub 2009 Jul 27.

From bending DNA to diabetes: the curious case of HMGA1.

Author information

  • 1Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QR, UK. rks16@cam.ac.uk

Abstract

Although mice lacking the architectural DNA binding factor HMGA1 are diabetic and express very low levels of the insulin receptor, they have increased insulin sensitivity. A study in BMC Biology now suggests that changes in circulating retinol binding protein partly account for this paradox.

PMID:
19664187
PMCID:
PMC2736670
DOI:
10.1186/jbiol164
[PubMed - indexed for MEDLINE]
Free PMC Article
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