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Br J Haematol. 2009 Oct;147(1):125-8. doi: 10.1111/j.1365-2141.2009.07844.x. Epub 2009 Aug 5.

International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia.

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Paediatric Haematology and Oncology, University of Frankfurt, Frankfurt, Germany.


This study described infection-related supportive care practices amongst centres participating in two large paediatric acute myeloid leukaemia (AML) cooperative groups, Children's Oncology Group (COG) and Berlin-Frankfurt-Muenster (BFM). We surveyed 216 COG and 55 BFM institutions. The overall survey response rate was 83.8%. Antibacterial prophylaxis was more common among BFM (15/46, 32.6%) compared to COG (24/180, 13.3%, P < 0.0001) institutions. Antifungal prophylaxis also was more common among BFM (42/46, 91.3%) compared to COG (137/178, 77.0%, P = 0.03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials.

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