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Thorac Surg Clin. 2009 May;19(2):247-53, ix-x. doi: 10.1016/j.thorsurg.2009.02.005.

Treatment of heterogeneous emphysema using the spiration IBV valves.

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School of Medicine, University of Washington, Seattle, WA, USA.


Ninety-eight emphysema patients were treated at 13 international sites during a 3-year series of single-arm, open-label studies with the IBV valve and a multi-lobar treatment approach. Fifty six percent of subjects had a clinically meaningful improvement in health-related quality of life, but standard pulmonary function and exercise studies were insensitive effectiveness measures. Quantitative CT analyses of regional lung changes showed lobar volume changes in over 85% of subjects. Lung volume reduction was an uncommon mechanism for a treatment response with bilateral upper lobe treatment. A redirection of inspired air, an interlobar shift to health-ier lung tissue, was the most common mechanism for a valve treatment response.

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