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Nat Prod Res. 2009;23(12):1063-71. doi: 10.1080/14786410802265415.

New antitumour fungal metabolites from Alternaria porri.

Author information

1
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. preecha.p@chula.ac.th

Abstract

Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).

PMID:
19662571
DOI:
10.1080/14786410802265415
[Indexed for MEDLINE]
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