New antitumour fungal metabolites from Alternaria porri

Nat Prod Res. 2009;23(12):1063-71. doi: 10.1080/14786410802265415.

Abstract

Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternaria / chemistry*
  • Alternaria / metabolism
  • Anthraquinones / chemistry
  • Anthraquinones / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Benzofurans / chemistry
  • Benzofurans / pharmacology
  • Colorimetry / methods
  • Drug Screening Assays, Antitumor / methods
  • HeLa Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • KB Cells / drug effects
  • Lactones / chemistry
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Phthalic Acids / chemistry
  • Phthalic Acids / pharmacology

Substances

  • Anthraquinones
  • Antineoplastic Agents
  • Benzofurans
  • Lactones
  • Phthalic Acids
  • phthalic acid
  • phthalide
  • alternariol