Format

Send to

Choose Destination
Clin Nutr. 2010 Feb;29(1):78-83. doi: 10.1016/j.clnu.2009.07.003. Epub 2009 Aug 5.

Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture.

Author information

1
Division of Bone Diseases, WHO Collaborating Centre for Osteoporosis and Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, University of Geneva, CH-1211 Geneva 14, Switzerland. thierry.chevalley@hcuge.ch

Abstract

BACKGROUND & AIMS:

In patients with recent hip fracture, reduced serum IGF-I in relation to protein undernutrition is frequent. Elevation of circulating IGF-I in response to a daily oral supplement of 20 g of casein was observed after 6 months. This study determined if the response to casein as compared to whey protein can be observed as early as after one week.

METHODS:

45 women were randomized after recent hip fracture in 3 groups receiving a preparation of 20 g of casein, an isocaloric supplement of 20 g of whey protein or an isocaloric supplement of 15 g of whey protein combined with 5 g of essential amino acids (a.a.).

RESULTS:

A similar significant elevation of serum IGF-I was already observed after 7 days for casein (+37.3 microg/L), whey (+29.4) and for whey+a.a. (+34.3). From day 7-28, no further significant rise in IGF-I was recorded.

CONCLUSION:

After one week of protein supplementation, the percent increase of IGF-I was of similar magnitude to that previously observed after 6 months of protein supplementation. It suggests that in hip fracture patients, long-term effects of various protein preparations on IGF-I could be predicted from changes observed as early as 7 days after the onset of supplementation.

PMID:
19660844
DOI:
10.1016/j.clnu.2009.07.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center