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Diabetes Res Clin Pract. 2009 Nov;86(2):e22-4. doi: 10.1016/j.diabres.2009.07.002. Epub 2009 Aug 5.

Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy.

Author information

1
Diabetes Research Group, Division of Reproduction and Endocrinology, King's College London, London Bridge, London, UK. afshan.malik@kcl.ac.uk

Abstract

We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

PMID:
19660820
DOI:
10.1016/j.diabres.2009.07.002
[Indexed for MEDLINE]

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