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Microbes Infect. 2009 Nov;11(13):1037-45. doi: 10.1016/j.micinf.2009.07.011. Epub 2009 Aug 4.

Infection by the Sylvio X10/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas' disease.

Author information

1
Department of Immunology, Biomedical Sciences Institute, University of São Paulo, Av. Professor Lineu Prestes, 1730, São Paulo, SP, CEP-05508-000, Brazil.

Abstract

The physiopathology of Chagas' disease has been largely defined in murine infections with virulent strains which partially represent parasite diversity. This report reviews our studies with Sylvio X10/4 parasites, a Trypanosoma cruzi clone that induces no acute phase but in C3H/He mice leads to chronic myocarditis resembling the human disease.

PMID:
19660570
DOI:
10.1016/j.micinf.2009.07.011
[Indexed for MEDLINE]

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