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Phys Rev Lett. 2009 Jul 10;103(2):024101. Epub 2009 Jul 8.

Weighted spike-triggered average of a fluctuating stimulus yielding the phase response curve.

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Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan.


We demonstrate that the phase response curve (PRC) can be reconstructed using a weighted spike-triggered average of an injected fluctuating input. The key idea is to choose the weight to be proportional to the magnitude of the fluctuation of the oscillatory period. Particularly, when a neuron exhibits random switching behavior between two bursting modes, two corresponding PRCs can be simultaneously reconstructed, even from the data of a single trial. This method offers an efficient alternative to the experimental investigation of oscillatory systems, without the need for detailed modeling.

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