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Eur J Clin Invest. 2009 Nov;39(11):953-9. doi: 10.1111/j.1365-2362.2009.02199.x. Epub 2009 Jul 27.

The role of matrix metalloproteinases in the pathogenesis of abdominal wall hernias.

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  • 1Krankenhaus Maria v. d. Aposteln Neuwerk, Mönchengladbach, Germany. stavros.antoniou@hotmail.com

Abstract

Surgical treatment of abdominal wall hernia has been based for many decades on observational evidence, as the disease physiopathology was ambiguous. The long-standing hypothesis of abnormal collagen metabolism as a causative factor of hernia disease seems to become substantiated by modern investigations, demonstrating a link between abnormal matrix metalloproteinase (MMP) expression and abdominal wall hernia. Current evidence suggests a strong correlation between MMP-2 and direct inguinal hernia, while the role of this MMP in indirect, incisional and recurrent hernias has not been completely elucidated yet. Furthermore, MMP-1 and MMP-13 seem to be implicated in the physiopathology of recurrent hernia, while limited data link MMP-1 also with incisional hernia formation. Despite the importance of MMP-9 in wound healing mechanisms, its role in hernia pathogenesis has not been adequately investigated. Future research is expected to decipher the complex physiopathological mechanisms of hernia development and provide a basis for potential therapeutic applications.

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