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Clin Endocrinol (Oxf). 2010 May;72(5):595-603. doi: 10.1111/j.1365-2265.2009.03676.x. Epub 2009 Jul 28.

Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans.

Author information

1
Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201, USA. avalina@med.wayne.edu

Abstract

BACKGROUND:

Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known.

OBJECTIVE:

To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures.

DESIGN:

A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial.

MEASUREMENTS:

Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH <or=65 pg/ml), (ii) low 25-OH D and normal PTH and (iii) low 25-OH D and high PTH.

RESULTS:

Age, gender and season-adjusted regression analyses showed that PTH was directly correlated with total (P = 0.02), truncal (P = 0.03) and extremity (P = 0.03) fat mass, while 25-OH D was inversely related to truncal fat mass (P = 0.02). Total fat mass in groups 1-3, respectively, was 30.0, 34.0 and 37.4 kg (P = 0.008); truncal fat mass was 13.4, 15.9 and 17.6 kg (P = 0.006) and extremity fat mass was 15.8, 16.9 and 19.7 kg (P = 0.02). Lean mass did not differ across the three groups.

CONCLUSIONS:

Our findings show that lower 25-OH D and raised PTH are both correlated, though in opposite directions, with fat mass, fat distribution and anthropometric measures in adult AA.

PMID:
19656160
PMCID:
PMC2866059
DOI:
10.1111/j.1365-2265.2009.03676.x
[Indexed for MEDLINE]
Free PMC Article
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