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Nucl Med Commun. 2009 Oct;30(10):763-9. doi: 10.1097/MNM.0b013e32832fa254.

Clinical significance of diffusely increased splenic uptake on FDG-PET.

Author information

1
Nuclear Medicine Service, Department of Radiology, University Hospital, UMDNJ, Newark, New Jersey 07103, USA. liuyl@umdnj.edu

Abstract

Diffusely increased uptake is more commonly observed than focal uptake in the spleen on a whole-body [F] fluorodeoxyglucose-positron emission tomography/computed tomography. The significance of diffusely increased splenic uptake varies in different clinical settings. On a pre-therapeutic scan for lymphoma, splenic uptake, greater than hepatic uptake, is a relative reliable indication of lymphomatous involvement of the spleen, unless the patient has a history of recent cytokine administration. In HIV infection, increased splenic uptake is usually noted in the early stage of the disease, which could reflect massive stimulation of B-cells in the spleen by nonreplicating antigenic material. Diffusely increased splenic uptake may also be present in sarcoidosis, malaria, and many inflammatory or hematopoietic diseases. Therapeutic-related reactive splenic uptake concurrent with bone marrow uptake is often secondary to administration of granulocyte colony-stimulating factor for myelosuppression or high-dose interferon-alpha-2b adjuvant therapy for melanoma.

PMID:
19654562
DOI:
10.1097/MNM.0b013e32832fa254
[Indexed for MEDLINE]

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