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Curr Opin Nephrol Hypertens. 2009 Nov;18(6):526-30. doi: 10.1097/MNH.0b013e328330d9d0.

Uric acid: a novel mediator and marker of risk in chronic kidney disease?

Author information

1
Baylor College of Medicine and Texas Children's Hospital, Houston, Texas 77030, USA. dfeig@bcm.edu

Abstract

PURPOSE OF REVIEW:

To assess the current data suggesting that uric acid-lowering therapy may be useful in the prevention or mitigation of chronic kidney disease (CKD).

RECENT FINDINGS:

Eleven observational studies assessing the potential role of serum uric acid in the prevalence and progression of CKD have been published in the past 2 years. Seven suggest an association, whereas four do not. Recent experimental models and clinical trials have mechanistically linked serum uric acid and hypertension, an established risk factor for CKD.

SUMMARY:

Elevated serum uric acid is a marker for decreased renal function, may have a mechanistic role in the incidence and progression of renal functional decline and likely has a causal role in hypertension and vascular disease. Clinical trials are needed to determine whether uric acid-lowering therapy will be effective in preventing CKD.

PMID:
19654543
PMCID:
PMC2885828
DOI:
10.1097/MNH.0b013e328330d9d0
[Indexed for MEDLINE]
Free PMC Article

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