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Genetics. 2009 Oct;183(2):747-9. doi: 10.1534/genetics.109.106005. Epub 2009 Aug 3.

Point mutation rate of bacteriophage PhiX174.

Author information

1
Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departamento de Genética, Universitat de València, 46071 València, Spain.

Abstract

The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying in DNA-based microorganisms).

PMID:
19652180
PMCID:
PMC2766332
DOI:
10.1534/genetics.109.106005
[Indexed for MEDLINE]
Free PMC Article

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