Format

Send to

Choose Destination
J Bone Joint Surg Br. 2009 Aug;91(8):987-96. doi: 10.1302/0301-620X.91B8.22546.

The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery: a review of the literature.

Author information

1
Kadoorie Trauma Research Unit Nuffield Department of Orthopaedic Rheumatology and Musculoskeletal Sciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX39DU, UK. josephalsousou@doctors.org.uk

Abstract

Although mechanical stabilisation has been a hallmark of orthopaedic surgical management, orthobiologics are now playing an increasing role. Platelet-rich plasma (PRP) is a volume of plasma fraction of autologous blood having platelet concentrations above baseline. The platelet alpha granules are rich in growth factors that play an essential role in tissue healing, such as transforming growth factor-beta, vascular endothelial growth factor, and platelet-derived growth factor. PRP is used in various surgical fields to enhance bone and soft-tissue healing by placing supraphysiological concentrations of autologous platelets at the site of tissue damage. The easily obtainable PRP and its possible beneficial outcome hold promise for new regenerative treatment approaches. The aim of this literature review was to describe the bioactivities of PRP, to elucidate the different techniques for PRP preparation, to review animal and human studies, to evaluate the evidence regarding the use of PRP in trauma and orthopaedic surgery, to clarify risks, and to provide guidance for future research.

PMID:
19651823
DOI:
10.1302/0301-620X.91B8.22546
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Bone and Joint Publishing
Loading ...
Support Center