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Trends Cell Biol. 2009 Aug;19(8):364-74. doi: 10.1016/j.tcb.2009.05.007. Epub 2009 Aug 3.

Scaffolds: interaction platforms for cellular signalling circuits.

Author information

1
Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117 Budapest, Hungary.

Abstract

Scaffold proteins influence cellular signalling by binding to multiple signalling enzymes, receptors or ion channels. Although normally devoid of catalytic activity, they have a big impact on controlling the flow of signalling information. By assembling signalling proteins into complexes, they play the part of signal processing hubs. As we learn more about the way signalling components are linked into natural signalling circuits, researchers are becoming interested in building non-natural signalling pathways to test our knowledge and/or to intentionally reprogram cellular behaviour. In this review, we discuss the role of scaffold proteins as efficient tools for assembling intracellular signalling complexes, both natural and artificial.

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PMID:
19651513
PMCID:
PMC3073007
DOI:
10.1016/j.tcb.2009.05.007
[Indexed for MEDLINE]
Free PMC Article

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