Dengue Fever (DF) with acute acalculous cholecystitis is a rare and atypical presentation. We report a case of dengue fever presenting as acute acalculous cholecystitis. The patient presented with abdominal pain, vomiting and fever. Her platelet counts were low and Dengue antibody test was positive. Ultrasound showed acute acalculous cholecystitis. The patient was successfully managed conservatively.