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Int J Geriatr Psychiatry. 2010 Apr;25(4):403-10. doi: 10.1002/gps.2353.

Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity.

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1
Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden. kajsa.samgard.923@student.lu.se

Abstract

OBJECTIVES:

The aim of this longitudinal study was to test the hypothesis that CSF biomarkers in AD patients also may be forward-looking measures that are associated not only with the degree and profile of cognitive impairment but also with changes in cognition over time.

METHODS:

Here, we assessed the association of CSF Abeta42, T-tau and P-tau with neuropsychological scores of disease severity, as well as the rate of disease progression, in 142 patients with Alzheimer's disease. All patients were part of a 3-year prospective longitudinal treatment study.

RESULTS:

A more rapid progress in MMSE score reduction was seen in AD patients with T-tau levels higher than the upper quartile (800 ng/L) compared with Alzheimer's disease patients with lower T-tau levels (p = 0.008). We also found that individuals with T-tau > 800 ng/L performed worse in total scores and especially in memory and orientation when assessed with MMSE and ADAS cog than patients with T-tau <800 ng/L. Similar results were obtained for P-tau. No associations were seen between Abeta42 and cognitive scores or disease progression.

DISCUSSION:

These findings support the hypothesis that increased levels of T-tau reflect the intensity of the disease and are associated with a more rapid disease progress.

PMID:
19650161
DOI:
10.1002/gps.2353
[Indexed for MEDLINE]
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