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Curr Opin Investig Drugs. 2009 Aug;10(8):787-94.

The relevance of the polymicrobial nature of airway infection in the acute and chronic management of patients with cystic fibrosis.

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Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada.


A comprehensive analysis of the airway microbiome in cystic fibrosis (CF) has revealed that the airways are a reservoir of previously unrecognized but clinically relevant organisms. Traditionally, antibiotic intervention in patients with CF presenting with acute bronchopulmonary exacerbations has been directed at a limited number of bacterial pathogens. In patients chronically colonized by conventional pathogens that demonstrate no bacteriological response to standard therapy, other antibiotics may have clinical efficacy. Using a case-based example, this review argues that pathogen-directed treatment based on inclusive quantitative microbiological protocols can result in improved patient outcomes. Furthermore, future therapeutic approaches that may rely on a polymicrobial perspective of the airways in CF are discussed.

[Indexed for MEDLINE]

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