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Opt Lett. 2009 Aug 1;34(15):2366-8.

Wide-field extended-resolution fluorescence microscopy with standing surface-plasmon-resonance waves.

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1
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

The resolution of conventional surface-plasmon-resonance (SPR) imaging has been limited by the diffraction nature of light. A wide-field extended-resolution optical imaging technique, standing-wave SPR fluorescence (SW-SPRF) microscopy, has been developed. Based on evanescent SPR standing waves, SW-SPRF provides lateral resolution approaching 100 nm and offers the advantages of significant signal enhancement and background-noise reduction. SW-SPRF has the potential for sensitive biomolecular detection, nanoscale imaging, and lithographic applications.

PMID:
19649099
PMCID:
PMC5542923
[Indexed for MEDLINE]
Free PMC Article
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