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Nat Cell Biol. 2009 Aug;11(8):919-21. doi: 10.1038/ncb0809-919.

Axon growth-stimulus package includes local translation.

Author information

1
Ian G. Macara, Hidekazu Iioka and Stavroula Mili are in the Center for Cell Signaling, University of Virginia, Charlottesville, VA 22908-0577, USA. igm9c@virginia.edu

Abstract

Translation of localized mRNAs is an important mechanism for controlling spatially discrete cellular processes. The polarity protein Par-3 is locally translated in axons in response to factors such as NGF and netrin-1, and this increased expression is necessary for factor-stimulated axonal outgrowth.

PMID:
19648976
PMCID:
PMC2877918
DOI:
10.1038/ncb0809-919
[Indexed for MEDLINE]
Free PMC Article

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