Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Endocrinol Metab. 2009 Aug;20(6):295-302. doi: 10.1016/j.tem.2009.03.005. Epub 2009 Jul 31.

eNOS, metabolic syndrome and cardiovascular disease.

Author information

1
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. phuang1@partners.org

Abstract

Large epidemiologic studies have established that diabetes, hyperlipidemia and obesity all increase the risk for cardiovascular disease. However, the precise mechanisms by which these metabolic disorders increase the propensity to develop atherosclerosis are not known. Recently, the concept of the metabolic syndrome - a constellation of conditions including obesity, hypertension, hyperlipidemia and insulin resistance - has received much attention. Studies on the metabolic syndrome might enable a better understanding of the underlying biological mechanisms that lead to cardiovascular disease. This review focuses on endothelial nitric oxide synthase and summarizes evidence that a reduction in the bioavailability of endothelium-derived nitric oxide serves as a key link between metabolic disorders and cardiovascular risk.

PMID:
19647446
PMCID:
PMC2731551
DOI:
10.1016/j.tem.2009.03.005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center