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Cancer Cell. 2009 Aug 4;16(2):87-8. doi: 10.1016/j.ccr.2009.07.005.

The SPS affair: a complex tale of illicit proliferation.

Author information

1
Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158, USA.

Abstract

In this issue of Cancer Cell, Xiao et al. report that PLC-beta3 mutant mice develop myeloprolfierative neoplasms and show that tumor suppressor activity does not require PLC-beta3 catalytic activity. Instead, PLC-beta3 forms a complex with SHP-1 and Stat5 that facilitates Stat5 dephosphorylation. A similar mechanism may be operative in some human leukemias.

PMID:
19647218
DOI:
10.1016/j.ccr.2009.07.005
[Indexed for MEDLINE]
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