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Cancer Cell. 2009 Aug 4;16(2):81-2. doi: 10.1016/j.ccr.2009.07.007.

Metastasis-promoting immunity: when T cells turn to the dark side.

Author information

1
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. dpardol1@jhmi.edu

Abstract

While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.

PMID:
19647215
DOI:
10.1016/j.ccr.2009.07.007
[Indexed for MEDLINE]
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